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Mesenchymal stem cells secretome : The cornerstone of cell-free regenerative medicine

Abstract: Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues, their ability of homing to injury sites and their potential to differentiate into multiple cell types. However, the realization that the beneficial effect of MSCs relies mainly on their paracrine action, rather than on their engraftment in the recipient tissue and subsequent differentiation, has opened the way to cell-free therapeutic strategies in regenerative medicine. All the soluble factors and vesicles secreted by MSCs are commonly known as secretome. MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immune-modulation and regeneration both in vitro and in vivo. Moreover, the use of secretome has key advantages over cell-based therapies, such as a lower immunogenicity and easy production, handling and storage. Importantly, MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals, thus, opening a large number of possibilities. Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts, enabling rapid scientific progress in this field.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: World J Stem Cells . 2020 Dec 26;12(12):1529-1552

Editorial: Baishideng Publishing Group

 Fecha de publicación: 01/12/2020

Nº de páginas: 24

Tipo de publicación: Artículo de Revista

 DOI: 10.4252/wjsc.v12.i12.0000

ISSN: 1948-0210

Proyecto español: RTI2018-097324

Url de la publicación: https://dx.doi.org/10.4252/wjsc.v12.i12.0000