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Epigenetic alterations of TGFß and its main canonical signaling mediators in the context of cardiac fibrosis

Abstract: Cardiac fibrosis is a pathological process that presents a continuous overproduction of extracellular matrix (ECM) components in the myocardium, which negatively influences the progression of many cardiac diseases. Transforming growth factor ? (TGF?) is the main ligand that triggers the production of pro-fibrotic ECM proteins. In the cardiac fibrotic process, TGF? and its canonical signaling mediators are tightly regulated at different levels as well as epigenetically. Cardiac fibroblasts are one of the most important TGF? target cells activated after cardiac injury. TGF?-driven fibroblast activation is subject to epigenetic modulation and contributes to the progression of cardiac fibrosis, mainly through the expression of pro-fibrotic molecules implicated in the disease. In this review, we describe epigenetic regulation related to canonical TGF? signaling in cardiac fibroblasts.

 Fuente: Journal of Molecular and Cellular Cardiology. Volume 159, October 2021, Pages 38-47

 Editorial: Elsevier

 Año de publicación: 2021

 Nº de páginas: 10

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.yjmcc.2021.06.003

 ISSN: 0022-2828,1095-8584

 Proyecto español: RTI2018-095214-B-I00; BIO2015-72124-EXP