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 Detalle_Publicacion

Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea

Abstract: Continuous positive airway pressure (CPAP) reduces blood pressure levels in hypertensive patients with obstructive sleep apnoea (OSA). However, the role of CPAP in blood pressure and the metabolic profile in women has not yet been assessed. In this study we investigated the effect of CPAP on blood pressure levels and the glucose and lipid profile in women with moderate-to-severe OSA.A multicentre, open-label, randomised controlled trial was conducted in 307 women diagnosed with moderate-to-severe OSA (apnoea-hypopnoea index ?15 events·h-1) in 19 Spanish Sleep Units. Women were randomised to CPAP (n=151) or conservative treatment (n=156) for 12 weeks. Changes in office blood pressure measures as well as in the glucose and lipid profile were assessed in both groups.Compared with the control group, the CPAP group achieved a significantly greater decrease in diastolic blood pressure (-2.04 mmHg, 95% CI -4.02- -0.05; p=0.045), and a nonsignificantly greater decrease in systolic blood pressure (-1.54 mmHg, 95% CI -4.58-1.51; p=0.32) and mean blood pressure (-1.90 mmHg, 95% CI -4.0-0.31; p=0.084). CPAP therapy did not change any of the metabolic variables assessed.In women with moderate-to-severe OSA, 12 weeks of CPAP therapy improved blood pressure, especially diastolic blood pressure, but did not change the metabolic profile, compared with conservative treatment.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Eur Respir J . 2017 Aug 10;50(2):1700257

Editorial: European Respiratory Society

 Año de publicación: 2017

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1183/13993003.00257-2017

ISSN: 0903-1936,1399-3003

Url de la publicación: https://doi.org/10.1183/13993003.00257-2017

Autoría

CAMPOS RODRIGUEZ, FRANCISCO

SANCHEZ ARMENGOL, ANGELES

JURADO GAMEZ, BERNABE

CORDERO GUEVARA, JOSE

REYES NUÑEZ, NURIA

TRONCOSO, MARIA F.

ABAD FERNANDEZ, ARACELI

TERAN SANTOS, JOAQUIN

CABALLERO RODRIGUEZ, JULIAN

MARTIN ROMERO, MERCEDES

ENCABO MOTIÑO, ANA

SACRISTAN BOU, LIRIOS

NAVARRO ESTEVA, JAVIER

SOMOZA GONZALEZ, MARIA

MASA, JUAN F.

SANCHEZ QUIROGA, MARIA A.

JARA CHINARRO, BEATRIZ

OROSA BERTOL, BELÉN

MARTINEZ-GARCIA, MIGUEL A.

SPANISH SLEEP NETWORK