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The cerebellum ages slowly according to the epigenetic clock

Abstract: Studies that elucidate why some human tissues age faster than others may shed light on how we age, and ultimately suggest what interventions may be possible. Here we utilize a recent biomarker of aging (referred to as epigenetic clock) to assess the epigenetic ages of up to 30 anatomic sites from supercentenarians (subjects who reached an age of 110 or older) and younger subjects. Using three novel and three published human DNA methylation data sets, we demonstrate that the cerebellum ages more slowly than other parts of the human body. We used both transcriptional data and genetic data to elucidate molecular mechanisms which may explain this finding. The two largest superfamilies of helicases (SF1 and SF2) are significantly over-represented (p=9.2x10-9) among gene transcripts that are over-expressed in the cerebellum compared to other brain regions from the same subject. Furthermore, SNPs that are associated with epigenetic age acceleration in the cerebellum tend to be located near genes from helicase superfamilies SF1 and SF2 (enrichment p=5.8x10-3). Our genetic and transcriptional studies of epigenetic age acceleration support the hypothesis that the slow aging rate of the cerebellum is due to processes that involve RNA helicases.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Steve Horvath, Vei Mah, Ake T. Lu, Jennifer S. Woo, OiWa Choi, Anna J. Jasinska, José A. Riancho, Spencer Tung, Natalie S. Coles, Jonathan Braun, Harry V. Vinters, and L. Stephen Coles

 Fuente: Aging (Albany NY). 2015 May;7(5):294-306

Editorial: Impact Journals, LLC

 Año de publicación: 2015

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.18632/aging.100742

ISSN: 1945-4589

Url de la publicación: https://doi.org/10.18632/aging.100742

Autores/as

HORVATH, S

MAH, V

LU, AT

WOO, JS

CHOY, OW

JASINSKA, AJ

COLES, NS

BRAUN, J

VINTERS, HV

COLES, LS