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Abstract: Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely
unexplored. We reconstructed the full DNA methylation maps of the Neandertal and the
Denisovan by harnessing the natural degradation processes of methylated and unmethylated
cytosines. Comparing these ancient methylation maps to those of present-day humans, we
identified ~2000 differentially methylated regions (DMRs). Particularly, we found substantial
methylation changes in the HOXD cluster that may explain anatomical differences between archaic
and present-day humans. Additionally, we found that DMRs are significantly more likely to be
associated with diseases. This study provides insight into the epigenetic landscape of our closest
evolutionary relatives and opens a window to explore the epigenomes of extinct species.
Fuente: Science. 2014 May 2;344(6183):523-7
Editorial: American Association for the Advancement of Science
Año de publicación: 2014
Nº de páginas: 5
Tipo de publicación: Artículo de Revista
JOSE ANTONIO RIANCHO MORAL