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Reconstructing the DNA methylation maps of the Neandertal and the Denisovan

Abstract: Ancient DNA sequencing has recently provided high-coverage archaic human genomes. However, the evolution of epigenetic regulation along the human lineage remains largely unexplored. We reconstructed the full DNA methylation maps of the Neandertal and the Denisovan by harnessing the natural degradation processes of methylated and unmethylated cytosines. Comparing these ancient methylation maps to those of present-day humans, we identified ~2000 differentially methylated regions (DMRs). Particularly, we found substantial methylation changes in the HOXD cluster that may explain anatomical differences between archaic and present-day humans. Additionally, we found that DMRs are significantly more likely to be associated with diseases. This study provides insight into the epigenetic landscape of our closest evolutionary relatives and opens a window to explore the epigenomes of extinct species.

 Fuente: Science, 2014, 344(6183), 523-527

 Editorial: American Association for the Advancement of Science

 Año de publicación: 2014

 Nº de páginas: 5

 Tipo de publicación: Artículo de Revista

 DOI: 10.1126/science.1250368

 ISSN: 0036-8075,1095-9203

 Url de la publicación: https://doi.org/10.1126/science.1250368

Autoría

GOKHMAN, D

LAVI, E

PRUFER, K

FRAGA, MF

PAABO, S

MESHORER, E

CARMEL, L