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Risk of gastric cancer in the environs of industrial facilities in the MCC-Spain study

Abstract: Background: Gastric cancer is the fifth most frequent tumor worldwide. In Spain, it presents a large geographic variability in incidence, suggesting a possible role of environmental factors in its etiology. Therefore, epidemiologic research focused on environmental exposures is necessary. Objectives: To assess the association between risk of gastric cancer (by histological type and tumor site) and residential proximity to industrial installations, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer conducted in Spain (MCC-Spain). Methods: In this study, 2664 controls and 137 gastric cancer cases from 9 provinces, frequency matched by province of residence, age, and sex were included. Distances from the individuals' residences to the 106 industries located in the study areas were computed. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industries, adjusting for matching variables and potential confounders. Results: Overall, no excess risk of gastric cancer was observed in people living close to the industrial installations, with ORs ranging from 0.73 (at ?2.5 km) to 0.93 (at ?1.5 km). However, by industrial sector, excess risks (OR; 95%CI) were found near organic chemical industry (3.51; 1.42-8.69 at ?2 km), inorganic chemical industry (3.33; 1.12-9.85 at ?2 km), food/beverage sector (2.48; 1.12-5.50 at ?2 km), and surface treatment using organic solvents (3.59; 1.40-9.22 at ?3 km). By specific pollutant, a statistically significant excess risk (OR; 95%CI) was found near (?3 km) industries releasing nonylphenol (6.43; 2.30-17.97) and antimony (4.82; 1.94-12.01). Conclusions: The results suggest no association between risk of gastric cancer and living in the proximity to the industrial facilities as a whole. However, a few associations were detected near some industrial sectors and installations releasing specific pollutants

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Environ Pollut . 2021 Jun 1;278:116854.

Editorial: Elsevier

 Año de publicación: 2021

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.envpol.2021.116854

ISSN: 0269-7491,1873-6424

Url de la publicación: https://doi.org/10.1016/j.envpol.2021.116854

Autores/as

GARCÍA-PÉREZ, JAVIER

LOPE, VIRGINIA

FERNÁNDEZ DE LARREA-BAZ, NEREA

MOLINA, ANTONIO J.

TARDÓN, ADONINA

ALGUACIL, JUAN

PÉREZ-GÓMEZ, BEATRIZ

MORENO, VÍCTOR

GUEVARA, MARCELA

CASTAÑO-VINYALS, GEMMA

JIMÉNEZ-MOLEÓN, JOSÉ J.

MOLINA-BARCELÓ, ANA

MARTÍN, VICENTE

KOGEVINAS, MANOLIS

POLLÁN, MARINA

ARAGONÉS, NURIA