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 Detalle_Publicacion

Do all antiphospholipid antibodies confer the same risk for major organ involvement in systemic lupus erythematosus patients?

Abstract: Objectives: We aimed to investigate the association between the different antiphospholipid antibodies (aPL) and both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) manifestations. Methods: Patients from the RELESSER registry, a Spanish retrospective, cross-sectional, forty-five hospital registry of adult SLE patients, were included. Results: Out of a total of 3,658 SLE patients, 1372 were aPL positive (555 of them fulfilled criteria for APS). All aPL types showed a negative association with cutaneous SLE manifestations. Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) were both associated with haematological, ophthalmological and neuropsychiatric manifestations. IgG isotypes were associated with a higher risk of lupus manifestations compared with IgM. We found that the risk of neuropsychiatric and ophthalmological manifestations significantly increased with a higher number of positive aPL whereas the risk of cutaneous symptoms showed a negative correlation. All types of aPL, and more strongly LA, were associated with non-criteria antiphospholipid syndrome (APS) manifestations such as thrombocytopenia and haemolytic anaemia. Moreover, LA and aCL (particularly IgG isotype) were also associated with Libman-Sacks endocarditis and cognitive impairment. This association was stronger with more than one positive aPL. All types of aPL were also associated with classic APS manifestations, although LA, IgG isotypes, and patients with more than one aPL displayed a higher risk. Conclusions: There is a hierarchy for aPL and the risk of APS and SLE manifestations. aCL, and especially LA, confer a higher risk for major organ involvement in SLE. IgG isotypes seem to have a more important role. The load of aPL confer a higher risk for APS and certain SLE manifestations.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clinical and Experimental Rheumatology, 2021, 39(3), 555-563

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2021

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autoría

LEYRE RIANCHO ZARRABEITIA

RÚA-FIGUEROA, IÑIGO

ALONSO, FERNANDO

GALINDO-IZQUIERDO, MARÍA

OVALLES, JUAN

OLIVÉ-MARQUÉS, ALEJANDRO

MENA VÁZQUEZ, NATALIA

CALVO-ALÉN, JAIME

MENOR ALMAGRO, RAÚL

TOMERO MURIEL, EVA

URIARTE ISACELAYA, ESTHER

BOTEANU, ALINA

ANDRES, MARIANO

FREIRE GONZÁLEZ, MERCEDES

SANTOS SOLER, GREGORIO

RUIZ-LUCEA, MARIA ESTHER

IBÁÑEZ-BARCELÓ, MÓNICA

CASTELLVÍ, IVÁN

GALISTEO, CARLOS