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Role of VEGF polymorphisms in the susceptibility and severity of interstitial lung disease

Abstract: The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Remuzgo-martínez S., Genre F., Pulito-cueto V., Atienza-mateo B., Cuesta V.M.M., Fernández D.I., Rozas S.M.F., Lera-gómez L., Lecue P.A., Ussetti M.P., Laporta R., Berastegui C., Solé A., Pérez V., Gafas A.D.P., Gualillo O., Cifrián J.M., López-mejías R., González-gay M.Á.,

 Fuente: Biomedicines . 2021 Apr 22;9(5):458

 Año de publicación: 2021

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/biomedicines9050458

ISSN: 2227-9059

Url de la publicación: https://doi.org/ 10.3390/biomedicines9050458

Autores/as

REMUZGO-MARTÍNEZ, SARA

GENRE, FERNANDA

PULITO-CUETO, VERÓNICA

BELÉN ATIENZA MATEO

MORA CUESTA, VÍCTOR MANUEL

DAVID ITURBE FERNANDEZ

FERNÁNDEZ ROZAS, SONIA MARÍA

LERA-GÓMEZ, LETICIA

ALONSO LECUE, PILAR

USSETTI, MARÍA PIEDAD

LAPORTA, ROSALÍA

BERASTEGUI, CRISTINA

SOLÉ, AMPARO

PÉREZ, VIRGINIA

PABLO GAFAS, ALICIA DE

GUALILLO, ORESTE

LÓPEZ-MEJÍAS, RAQUEL