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Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association

Abstract: Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7-23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients' survival. In fact, while the 52-week survival of the overall population was 71.4 ± 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: J Clin Med . 2021 Jun 9;10(12):2548

Editorial: MDPI

 Año de publicación: 2021

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm10122548

ISSN: 2077-0383

Url de la publicación: https:// doi.org/10.3390/jcm10122548

Autoría

SEBASTIANI, MARCO

LUPPI, FABRIZIO

SAMBATARO, GIANLUCA

CASTILLO VILLEGAS, DIEGO

CERRI, STEFANIA

TOMIETTO, PAOLA

CASSONE, GIULIA

BOCCHINO, MARIALUISA

BELÉN ATIENZA MATEO

CAMELI, PAOLO

MOYA ALVARADO, PATRICIA

FAVERIO, PAOLA

BARGAGLI, ELENA

VANCHERI, CARLO

SALVARANI, CARLO

MANFREDI, ANDREINA