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 Detalle_Publicacion

Linezolid for infective endocarditis. A structured approach based on a national database experience

Abstract: Current data on the frequency and efficacy of linezolid (LNZ) in infective endocarditis (IE) are based on small retrospective series. We used a national database to evaluate the effectiveness of LNZ in IE. This is a retrospective study of IE patients in the Spanish GAMES database who received LNZ. We defined 3 levels of therapeutic impact: LNZ 50% of the total treatment, and > 50% of the LNZ doses prescribed in the first weeks of treatment), and LNZ ? 7 days not fulfilling the high-impact criteria (LNZ-NHI). Effectiveness of LNZ was assessed using propensity score matching and multivariate analysis of high-impact cases in comparison to patients not treated with LNZ from the GAMES database matched for age-adjusted comorbidity Charlson index, heart failure, renal failure, prosthetic and intracardiac IE device, left-sided IE, and Staphylococcus aureus. Primary outcomes were in-hospital mortality and one-year mortality. Secondary outcomes included IE complications and relapses.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Medicine: December 23, 2021 - Volume 100 - Issue 51 - p e27597

Editorial: Lippincott Williams & Wilkins

 Fecha de publicación: 23/12/2021

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1097/MD.0000000000027597

ISSN: 0025-7974,1536-5964

Url de la publicación: http://dx.doi.org/10.1097/MD.0000000000027597

Autores/as

MUÑOZ, P.

DE LA VILLA. S.

MARTÍNEZ-SELLÉS, M.

GOENAGA, M. A.

GARCÍA-CUELLO, L.

HIDALGO-TENORIO, C.

RODRÍGUEZ-ESTEBAN, M. A.

ANTORRENA, I.

CASTELO-CORRAL, L.

GARCÍA-VÁZQUEZ, E.

DE LA TORRE, J.

BOUZA, E.