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Malignancy following heart transplantation:differences in incidence and prognosis betweensexes - a multicenter cohort study

Abstract: Male patients are at increased risk for developing malignancy posthearttransplantation (HT); however, real incidence and prognosis in both gen-ders remain unknown. The aim of this study was to assess differences inincidence and mortality related to malignancy between genders in a largecohort of HT patients. Incidence and mortality rates were calculated for alltumors, skin cancers (SCs), lymphoma, and nonskin solid cancers (NSSCs)as well as survival since first diagnosis of neoplasia. 5865 patients (81.6%male) were included. Total incidence rates for all tumors, SCs, and NSSCswere lower in females [all tumors: 25.7 vs. 44.8 per 1000 person-years; rateratio (RR) 0.68, (0.60?0.78),P<0.001]. Mortality rates were also lower infemales for all tumors [94.0 (77.3?114.3) vs. 129.6 (120.9?138.9) per 1000person-years; RR 0.76, (0.62?0.94),P=0.01] and for NSSCs [125.0(95.2?164.0) vs 234.7 (214.0?257.5) per 1000 person-years; RR 0.60(0.44?0.80),P=0.001], albeit not for SCs or lymphoma. Female sex wasassociated with a better survival after diagnosis of malignancy [log-rank ptest=0.0037; HR 0.74 (0.60?0.91),P=0.004]. In conclusion, incidence ofmalignancies post-HT is higher in males than in females, especially for SCsand NSSCs. Prognosis after cancer diagnosis is also worse in males.

 Fuente: Transplant International2021; 34: 882-893

 Editorial: Blackwell Publishing Ltd

 Fecha de publicación: 12/03/2021

 Nº de páginas: 12

 Tipo de publicación: Artículo de Revista

 DOI: doi.org/10.1111/tri.13827

 ISSN: 0934-0874,1432-2277

 Url de la publicación: https://doi.org/10.1111/tri.13827

Autoría

MINGUITO-CARAZO, CARLOS

GÓMEZ-BUENO, MANUEL

ALMENAR-BONET, LUIS

BARGE-CABALLERO, EDUARDO

DELGADO-JIMÉNEZ, JUAN F.

ARIZÓN DEL PRADO, JOSÉ MARÍA

SOUSA-CASASNOVAS, IAGO

MIRABET-PÉREZ, SÓNIA

GONZÁLEZ-COSTELLO, JOSÉ

SOBRINO-MÁRQUEZ, JOSÉ MANUEL

PÉREZ-VILLA, FÉLIX

DÍAZ-MOLINA, BEATRIZ

RÁBAGO JUAN-ARACIL, GREGORIO

BLASCO-PEIRÓ, TERESA

FUENTE GALÁN, LUIS DE LA

GARRIDO-BRAVO, IRIS

GARCÍA-GUERETA, LUIS

CAMINO, MANUELA

ALBERT-BROTONS, DIMPNA C.