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Assessment of aortitis by semiquantitative analysis of 180-min 18F-FDG PET/CT acquisition images

Abstract: PURPOSE: The aim of this study was to evaluate the contribution of semiquantitative analysis of 180-min (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images for the assessment of aortitis in cases of suspected large vessel vasculitis (LVV) and to establish a threshold index for application in the clinical setting. METHODS: This prospective study included 43 patients (mean age 67.5 ± 12.9 years) with suspicion of LVV (25 with a final diagnosis of aortitis). (18)F-FDG PET/CT scan was acquired 180 min after injection of 7 MBq/kg of (18)F-FDG. A semiquantitative analysis was performed calculating the aortic wall maximum standardized uptake value (SUVmax) (T), the lumen SUVmax (B) and the target to background ratio (TBR). These results were also compared with those obtained in a control population. RESULTS: The mean aortic wall SUVmax was 2.00 ± 0.62 for patients with aortitis and 1.45 ± 0.31 for patients without aortitis (p < 0.0001). The TBR was 1.66 ± 0.26 for patients with aortitis and 1.24 ± 0.08 for patients without aortitis (p < 0.0001). The differences were also statistically significant when the patients with aortitis and controls were compared. Receiver-operating characteristic (ROC) analysis revealed that the area under the curve was greater for the TBR than for the aortic wall SUVmax (0.997 vs 0.871). The highest sensitivity and specificity was obtained for a TBR of 1.34 (sensitivity 100%, specificity 94.4%). CONCLUSION: Semiquantitative analysis of PET/CT images acquired 180 min after (18)F-FDG injection and the TBR index of 1.34 show very high accuracy and, therefore, are strongly recommended for the diagnosis of aortitis in the clinical setting

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Eur J Nucl Med Mol Imaging. 2014 Dec;41(12):2319-24

Editorial: Springer-Verlag Berlin

 Año de publicación: 2014

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s00259-014-2863-y

ISSN: 1619-7070,1619-7089

Autoría

ISABEL MARTINEZ RODRIGUEZ

MARTÍNEZ AMADOR, N

JULIO FRANCISCO JIMENEZ BONILLA

ARCOCHA TORRES DE, M

IBAÑEZ BRAVO, S

LAVADO PÉREZ, C

BRAVO FERRER, Z

JOSE MANUEL CARRIL CARRIL