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 Detalle_Publicacion

Allogeneic stem cell transplantation in mantle cell lymphoma; insights into its potential role in the era of new immunotherapeutic and targeted therapies: the GETH/GELTAMO experience

Abstract: Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. The primary endpoints were EFS, OS, and cumulative incidence (CI) of NRM, relapse, and GVHD. We included 135 patients, most (85%) receiving RIC. After a median follow-up of 68 months, 5-year EFS and OS were 47 and 50%, respectively. Overall and CR rates were 86 and 80%. The CI of relapse at 1 and 3 years were 7 and 12%. NRM at day 100 and 1 year were 17 and 32%. Previous ASCT and Grade 3-4 aGVHD were associated with a higher NRM. Grade 3-4 aGVHD, donor type (mismatch non-related), and the time-period 2006-2020 were independently related to worse EFS. Patients from 1995-2005 were younger, most from HLA-identical sibling donors, and were pretreated less. Our data confirmed that allo-SCT may be a curative option in R/R MCL with low a CI of relapse, although NRM is still high, being mainly secondary to aGVHD. The arrival of new, highly effective and low toxic immunotherapeutic or targeted therapies inevitably will relegate allo-SCT to those fit patients who fail these therapies, far away from the optimal timing of treatment.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Cancers, 2022, 14(11), 2673

Editorial: MDPI

 Año de publicación: 2022

Nº de páginas: 16

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/cancers14112673

ISSN: 2072-6694

Url de la publicación: https://doi.org/10.3390/ cancers14112673

Autoría

GUTIERREZ, ANTONIO

BENTO, LEYRE

NOVELLI, SILVANA

MARTIN, ALEJANDRO

GUTIERREZ, GONZALO

QUERALT SALAS, MARIA

BASTOS-OREIRO, MARIANA

PEREZ, ARIADNA

HERNANI, RAFAEL

CRUZ VIGURIA, MARIA

LOPEZ-GODINO, ORIANA

MONTORO, JUAN

PIÑANA, JOSE LUIS

FERRA, CHRISTELLE

PARODY, ROCIO

MARTIN, CARMEN

ESPAÑOL, IGNACIO

RODRIGUEZ, GUILLERMO

ZANABILI, JOUD