Estamos realizando la búsqueda. Por favor, espere...
1551
37
173
26083
4132
2532
334
Abstract: Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
Fuente: Molecular Psychiatry, 2022, 27, 3731-3737 - (CORRIGENDUM) 2022, 27, 3738
Editorial: Nature Publishing Group
Fecha de publicación: 14/06/2022
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
DOI: 10.1038/s41380-022-01616-5
ISSN: 1359-4184,1476-5578
Url de la publicación: https://doi.org/10.1038/s41380-022-01616-5
Leer publicación
MCWHINNEY, SEAN R.
BROSCH, KATHARINA
CALHOUN, VINCE D.
BENEDICTO CRESPO FACORRO
CROSSLEY, NICOLAS A.
DANNLOWSKI, UDO
DICKIE, ERIN
DIETZE, LORIELLE M. F.
DONOHOE, GARY
PLESSIS, STEFAN DU
EHRLICH, STEFAN
EMSLEY, ROBIN
FURSTOVA, PETRA
GLAHN, DAVID C.
GONZÁLEZ-VALDERRAMA, ALFONSO
GROTEGERD, DOMINIK
HOLLERAN, LAURENA
KIRCHER, TILO T. J.
DIANA TORDESILLAS GUTIERREZ
JAVIER VAZQUEZ BOURGON
Volver