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Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment

Abstract: OHS patients have higher morbidity and mortality rates. Exosomes are released into the bloodstream and play a role in tumor growth and metastasis. Twenty-four OHS patients (13 male and 11 female) were evaluated at diagnosis (Pre), and after CPAP treatment (T3, T12 and T24 months). Plasma exosomes were applied into naïve NCI-H23 lung cancer cells. Exosomes from OHS patients enhance PMI of human lung cancer cells, and these effects are at least partially reversible with adherent CPAP treatment. Our findings suggest that OHS-induced changes in exosome cargo promote cancer aggressiveness in NCI-H23 lung adenocarcinoma and exhibit OHS treatment-related reversibility.

 Fuente: Biochimica et Biophysica Acta. Molecular Basis of Disease, 2022, 1868(10), 166479

Editorial: Elsevier

 Año de publicación: 2022

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.bbadis.2022.166479

ISSN: 0925-4439,1879-260X

Url de la publicación: https://doi.org/10.1016/j.bbadis.2022.166479

Autoría

KHALYFA, ABDELNABY

MASA, JUAN F

QIAO, ZHUANHONG

MARTI, SERGI

KHALYFA, AHAMED A

KHEIRANDISH-GOZAL, LEILA

GOZAL, DAVID