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Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease

Abstract: Background and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (? = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Eur J Neurol . 2022 Dec;29(12):3720-3727

Editorial: Wiley

 Año de publicación: 2022

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/ene.15513

ISSN: 1351-5101,1468-1331

Url de la publicación: https://doi.org/10.1111/ene.15513

Autoría

SAMPEDRO, FREDERIC

MARTÍNEZ-HORTA, SAUL

HORTA-BARBA, ANDREA

GROTHE, MICHEL J.

LABRADOR-ESPINOSA, MIGUEL A.

JESÚS, SILVIA

ADARMES-GÓMEZ, ASTRID

CARRILLO, FATIMA

PUIG-DAVI, ARNAU

ROLDÁN-LORA, FLORINDA

AGUILAR-BARBERA, MIQUEL

PASTOR, PAU

ESCALANTE ARROYO, SONIA

SOLANO VILA, BERTA

COTS-FORASTER, ANNA

RUIZ-MARTÍNEZ, JAVIER

CARRILLO-PADILLA, FRANCISCO

PUEYO-MORLANS, MERCEDES

ISABEL GONZALEZ ARAMBURU