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Outcome of liver cancer patients with SARS-CoV-2 infection: An International, Multicentre, Cohort Study

Abstract: Background & aims: Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. Methods: Multicentre retrospective, cross-sectional, international study of liver cancer patients with SARS-CoV-2 infection registered between February and December 2020. Clinical data at SARS-CoV-2 diagnosis and outcomes were registered. Results: Two hundred fifty patients from 38 centres were included, 218 with hepatocellular carcinoma (HCC) and 32 with intrahepatic cholangiocarcinoma (iCCA). The median age was 66.5 and 64.5 years, and 84.9% and 21.9% had cirrhosis in the HCC and iCCA cohorts respectively. Patients had advanced cancer stage at SARS-CoV-2 diagnosis in 39.0% of the HCC and 71.9% of the iCCA patients. After a median follow-up of 7.20 (IQR: 1.84-11.24) months, 100 (40%) patients have died, 48% of the deaths were SARS-CoV-2-related. Forty (18.4%) HCC patients died within 30-days. The death rate increase was significantly different according to the BCLC stage (6.10% [95% CI 2.24-12.74], 11.76% [95% CI 4.73-22.30], 20.69% [95% CI 11.35-31.96] and 34.52% [95% CI 17.03-52.78] for BCLC 0/A, B, C and D, respectively; p = .0017). The hazard ratio was 1.45 (95% CI 0.49-4.31; p = .5032) in BCLC-B versus 0/A, and 3.13 (95% CI 1.29-7.62; p = .0118) in BCLC-C versus 0/A in the competing risk Cox regression model. Nineteen out of 32 iCCA (59.4%) died, and 12 deaths were related to SARS-CoV-2 infection. Conclusions: This is the largest cohort of liver cancer patients infected with SARS-CoV-2. It characterizes the 30-day mortality risk of SARS-CoV-2 infected patients with HCC during this period.

 Fuente: Liver International. 2022;42:1891-1901

 Editorial: Wiley-Blackwell

 Fecha de publicación: 01/08/2022

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.1111/liv.15320

 ISSN: 1478-3223,1478-3231

 Url de la publicación: https://doi.org/10.1111/liv.15320

Autoría

MUÑÓZ-MARTÍNEZ, SERGIO

SAPENA, VÍCTOR

FORNER, ALEJANDRO

BRUIX, JORDI

SANDUZZI-ZAMPARELLI, MARCO

RÍOS, JOSÉ

BOUATTOUR, MOHAMED

EL-KASSAS, MOHAMED

LEAL, CASSIA R. G.

MOCAN, TUDOR

NAULT, JEAN-CHARLES

ALVES, ROGERIO C. P.

REEVES, HELEN L.

FONSECA, LEONARDO DA

GARCÍA-JUÁREZ, IGNACIO

PINATO, DAVID J.

VARELA, MARÍA

ALQAHTANI, SALEH A.

ALVARES-DA-SILVA, MARIO