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 Detalle_Publicacion

Development and validation of a nomogram to predict kidney survival at baseline in patients with C3 glomerulopathy

Abstract: Background: C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It is often challenging to accurately predict in clinical practice the individual kidney prognosis at baseline. We herein sought to develop and validate a prognostic nomogram to predict long-term kidney survival. Methods: We conducted a retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. The dataset was randomly divided into a training group (n = 87) and a validation group (n = 28). The least absolute shrinkage and selection operator (LASSO) regression was used to screen the main predictors of kidney outcome and to build the nomogram. The accuracy of the nomogram was assessed by discrimination and risk calibration in the training and validation sets. Results: The study group comprised 115 patients, of whom 46 (40%) reached kidney failure in a median follow-up of 49 months (range 24?112). No significant differences were observed in baseline estimated glomerular filtration rate (eGFR), proteinuria or total chronicity score of kidney biopsies, between patients in the training versus those in the validation set. The selected variables by LASSO were eGFR, proteinuria and total chronicity score. Based on a Cox model, a nomogram was developed for the prediction of kidney survival at 1, 2, 5 and 10 years from diagnosis. The C-index of the nomogram was 0.860 (95% confidence interval 0.834?0.887) and calibration plots showed optimal agreement between predicted and observed outcomes. Conclusions: We constructed and validated a practical nomogram with good discrimination and calibration to predict the risk of kidney failure in C3 glomerulopathy patients at 1, 2, 5 and 10 years.

 Fuente: Clinical Kidney Journal, 2022, 15(9), 1737-1746

Editorial: Oxford University Press

 Año de publicación: 2022

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/ckj/sfac108

ISSN: 2048-8505,2048-8513

Url de la publicación: https://doi.org/10.1093/ckj/sfac108

Autoría

CARAVACA-FONTÁN, FERNANDO

RIVERO, MARTA

CAVERO, TERESA

DÍAZ-ENCARNACIÓN, MONTSERRAT

CABELLO, VIRGINIA

ARICETA, GEMA

QUINTANA, LUIS F.

MARCO, HELENA

BARROS, XOANA

RAMOS, NATALIA

RODRÍGUEZ-MENDIOLA, NURIA

CRUZ, SONIA

FERNÁNDEZ-JUÁREZ, GEMA

RODRÍGUEZ, ADELA

PÉREZ DE JOSÉ, ANA

RABASCO, CRISTINA

RODADO, RAQUEL

FERNÁNDEZ, LORETO

PÉREZ-GÓMEZ, VANESSA

LUIS MARTIN PENAGOS