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Safety and immediate humoral response of COVID-19 vaccines in chronic kidney disease patients: the SENCOVAC study

Abstract: Background: Chronic kidney disease (CKD) patients are at high-risk for severe coronavirus disease 2019 (COVID-19). The multicentric, observational and prospective SENCOVAC study aims to describe the humoral response and safety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in CKD patients. Safety and immediate humoral response results are reported here. Methods: Four cohorts of patients were included: kidney transplant (KT) recipients, and haemodialysis (HD), peritoneal dialysis (PD) and non-dialysis CKD patients from 50 Spanish centres. Adverse events after vaccine doses were recorded. At baseline and on Day 28 after the last vaccine dose, anti-Spike antibodies were measured and compared between cohorts. Factors associated with development of anti-Spike antibodies were analysed. Results: A total of 1746 participants were recruited: 1116 HD, 171 PD, 176 non-dialysis CKD patients and 283 KT recipients. Most patients (98%) received mRNA vaccines. At least one vaccine reaction developed after the first dose in 763 (53.5%) and after the second dose in 741 (54.5%) of patients. Anti-Spike antibodies were measured in the first 301 patients. At 28 days, 95% of patients had developed antibodies: 79% of KT, 98% of HD, 99% of PD and 100% of non-dialysis CKD patients (P < 0.001). In a multivariate adjusted analysis, absence of an antibody response was independently associated with KT (odds ratio 20.56, P = 0.001) and with BNT162b2 vaccine (odds ratio 6.03, P = 0.023). Conclusion: The rate of anti-Spike antibody development after vaccination in KT patients was low but in other CKD patients it approached 100%, suggesting that KT patients require persistent isolation measures and booster doses of a COVID-19 vaccine. Potential differences between COVID-19 vaccines should be explored in prospective controlled studies.

 Fuente: Nephrol Dial Transplant . 2022 Sep 22;37(10):1868-1878

 Editorial: Oxford University Press

 Año de publicación: 2022

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.1093/ndt/gfab313

 ISSN: 0931-0509,1460-2385

 Url de la publicación: https://doi.org/10.1093/ndt/gfab313

Autoría

QUIROGA, BORJA

SOLER, MARÍA JOSÉ

ORTIZ, ALBERTO

MARTÍNEZ VAQUERA, SHAIRA

JARAVA MANTECÓN, CARLOS JESÚS

USECHE, GUSTAVO

SÁNCHEZ MÁRQUEZ, MARÍA GABRIELA

CARNERERO, MANUEL

JALDO RODRÍGUEZ, MARÍA TERESA

MUÑOZ RAMOS, PATRICIA

TOAPANTA, NESTOR

GRACIA-IGUACEL, CAROLINA

AGUILAR CERVERA, MARÍA CINTA

BALIBREA LARA, NOELIA

LEYVA, ALBA

ROJAS, JOSÉ

GANSEVOORT, RON T

DE SEQUERA, PATRICIA