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Predictors of thrombosis and bleeding in 1613 myelofibrosis patients from the Spanish Registry of Myelofibrosis

Abstract: Available data have proved insufficient to develop consensus recommendations on the prevention of thrombosis and bleeding in myelofibrosis (MF). We evaluated the incidence and risk factors of vascular complications in 1613 patients from the Spanish Myelofibrosis Registry. Over a total of 6981 patient-years at risk, 6.4% of the study population had at least one thrombotic event after MF diagnosis, amounting to an incidence rate of 1.65 per 100 patient-years. Prior history of thrombosis, the JAK2 mutation, and the intermediate-2/high-risk International Prognostic Scoring System (IPSS) categories conferred an increased thrombotic risk after adjustment for the risk-modifying effect of anti-thrombotic and cytoreductive treatments. History of thrombosis and the JAK2 mutation allowed us to pinpoint a group of patients at higher risk of early thrombosis. No decreased incidence of thrombosis was observed while patients were on anti-thrombotic or cytoreductive treatment. An increased risk of venous thrombosis was found during treatment with immunomodulatory agents. A total of 5.3% of patients had at least one episode of major bleeding, resulting in an incidence rate of 1.5 events per 100 patient-years. Patients in the intermediate-2/high-risk IPSS categories treated with anti-coagulants had an almost sevenfold increased risk of major bleeding. These findings should prove useful for guiding decision-making in clinical practice.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: British Journal of Haematology, 2022, 199(4), 529-538

Editorial: Blackwell Publishing Ltd

 Fecha de publicación: 12/09/2022

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/bjh.18440

ISSN: 0007-1048,1365-2141

 Proyecto español: PI21/00538

Url de la publicación: https://doi.org/10.1111/bjh.18440

Autoría

HERNÁNDEZ-BOLUDA, JUAN-CARLOS

PASTOR-GALÁN, IRENE

ARELLANO-RODRIGO, EDUARDO

RAYA, JOSÉ-MARÍA

PÉREZ-ENCINAS, MANUEL

AYALA, ROSA

FERRER-MARÍN, FRANCISCA

VÉLEZ, PATRICIA

MORA, ELVIRA

FOX, MARÍA-LAURA

HERNÁNDEZ-RIVAS, JESÚS-MARÍA

XICOY, BLANCA

MATA-VÁZQUEZ, MARÍA-ISABEL

GARCÍA-FORTES, MARÍA

PÉREZ-LÓPEZ, RAÚL

ANGONA, ANNA

CUEVAS, BEATRIZ

SENÍN, ALICIA

RAMÍREZ, MARÍA-JOSÉ

SONIA GONZALEZ DE VILLAMBROSIA