Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease

Abstract: Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50?90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score ?22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.?1.0. The Quality of Life in Alzheimer ?s Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman?s rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: J Alzheimers Dis . 2022;90(2):719-726

Editorial: IOS Press

 Año de publicación: 2022

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.3233/JAD-220696

ISSN: 1387-2877,1875-8908

Url de la publicación: https://doi.org/10.3233/JAD-220696

Autoría

VILLAREJO-GALENDE, ALBERTO

GARCÍA-ARCELAY, ELENA

PIÑOL-RIPOLL, GERARD

OLMO-RODRÍGUEZ, ANTONIO DEL

VIÑUELA, FÉLIX

BOADA, MERCÈ

FRANCO-MACÍAS, EMILIO

IBÁÑEZ DE LA PEÑA, ALMUDENA

RIVEROL, MARIO

PUIG-PIJOAN, ALBERT

ABIZANDA-SOLER, PEDRO

ARROYO, RAFAEL

BAQUERO-TOLEDO, MIQUEL

FERIA-VILAR, INMACULADA

BALASA, MIRCEA

BERBEL, ÁNGEL

VIEIRA-CAMPOS, ALBA

GARCÍA-RIBAS, GUILLERMO

RODRIGO-HERRERO, SILVIA