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Post-transplant diabetes mellitus and renal cell cancer after renal transplantation

Abstract: Background Diabetes is a risk factor for cancer in the general population. However, few data is available on the association between post-transplant diabetes mellitus (PTDM) and cancer after transplantation. Methods We analyzed this issue in a Spanish cohort of patients without diabetes before transplantation. PTDM was diagnosed with consensus criteria at 12 months after transplantation and 12 months before the diagnosis of cancer. The association between PTDM and cancer (overall and specific types) was evaluated with regression analysis. Results During a follow-up of 12 years (IQR:8?14), 85 cases of 603 developed cancer (829/100 000/year) and 164 (27%) PTDM. The most frequent cancers were renal cell cancer (RCC) n = 15; 146/cases/100 000/year), lung (n = 12, 117/cases/100 000/year); colon (n = 9, 88/cases/100 000/year) and prostate (n = 9, 88/cases/100 000/year). In logistic regression, PTDM was not associated with cancer. Eight of the 164 patients with PTDM (4.9%) vs. 7 of the 439 without PTDM developed RCC (1.6%): p = 0.027. In multivariate analysis, PTDM was independently associated with RCC (OR: 2.92, CI:1.03?8.27), adjusting for smoking (OR:4.020, CI:1.34?12.02) and other covariates. PTDM was not associated with other types of cancer. Conclusions Patients with PTDM must be considered a population at risk for RCC and accordingly, susceptible of active surveillance.

 Fuente: Nephrology Dialysis Transplantation, gfac291

 Editorial: Oxford University Press

 Fecha de publicación: 01/11/2022

 Tipo de publicación: Artículo de Revista

 DOI: 10.1093/ndt/gfac291

 ISSN: 0931-0509,1460-2385

 Url de la publicación: https://doi.org/10.1093/ndt/gfac291

Autoría

PORRINI, ESTEBAN

MONTERO, PÉREZ

MANUEL DÍAZ, JUAN

LAUZURRICA, RICARDO

ORAMAS RODRÍGUEZ, JUANA

SILVA TORRES, IRENE

MORESO, FRANCESC

CRUZADO GARRIT, JOSEP M.

BENÍTE RUIZ, ROCÍO

IBERNON VILARÓ, MERITXEL

MOLLINA LIMA, MARÍA XIXIANG

KHEMLANI RAMCHAND, SIMRAN

GAINZA DE LOS RÍOS, FRANCISCO

RODRÍGUEZ ÁLVAREZ, CARLA

GRACIA GUINDO, MARÍA DEL CARMEN DE

MACÍAS, MANUEL

BONET VELA, DAVID

OSUNA, ANTONIO

BAYÉS-GENÍS, BEATRIZ