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Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Abstract: Objective: The 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations provide an evidence-based guide for selecting therapy based on the individual's disease features. Beyond the disease features and associated conditions (eg, uveitis and inflammatory bowel disease), comorbidities play an important role in selecting therapy for an individual patient. Methods: We performed a systematic literature review. We examined the available evidence to inform treatment selection based on the presence or absence of comorbidities in psoriatic arthritis (PsA). Results: Common comorbidities in PsA that may affect treatment selection include presence of baseline cardiovascular disease (CVD) or high risk for CVD, obesity and metabolic syndrome, liver disease, mood disorders, including depression in particular, chronic infections, malignancies, osteoporosis, and fibromyalgia and/or central sensitization. Conclusion: Comorbidities may influence both the effectiveness of a given therapy but also the potential for adverse events. It is important to assess for the presence of comorbidities prior to therapy selection.

 Fuente: The Journal of Rheumatology November 2022, jrheum.220310

 Editorial: The Journal of Rheumatology Publishing Company Limited

 Año de publicación: 2022

 Nº de páginas: 7

 Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.220310

 ISSN: 0315-162X

 Url de la publicación: https://doi.org/10.3899/jrheum.220310

Autoría

CAMPANHOLO, CRISTIANO B.

MAHARAJ, AJESH B.

CORP, NADIA

BELL, STACIE

COSTA, LUISA

VLAM, KURT DE

GULLICK, NICOLA J.

KHRAISHI, MAJED

KISHIMOTO, MITSUMASA

NATALIA PALMOU FONTANA

REDDY, SOUMYA

SCARPA, RAFFAELE

VEGA, LUIS

VIEIRA DUARTE, GLEISON

ZISMAN, DEVY

VAN DER WINDT, DANIELLE A.

DURUOZ, MEHMET T.

OGDIE, ALEXIS