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Outcome of chimeric antigen receptor T-cell therapy following treatment with inotuzumab ozogamicin in children with relapsed or refractory acute lymphoblastic leukemia

Abstract: Chimeric antigen receptor T cells targeting CD19 (CART-19) have shown remarkable efficacy for relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukemia (BCP-ALL). We investigated whether prior use of inotuzumab ozogamicin (InO), an anti-CD22 antibody conjugated to calicheamicin, may impact CAR T-cell manufacturing or efficacy via pre-CART-19 depletion of the B-cell compartment. In this international, retrospective analysis, 39 children and young adults receiving InO before (n?=?12) and/or after (n?=?27) T-cell apheresis as bridging therapy to CART-19 treatment were analyzed. Median age at infusion was 13 years (range 1.4?23 years). Thirty-four out of 39 patients (87.2%) obtained complete remission. With a median follow-up of 18.2 months after CART-19 infusion, 12-month event-free survival (EFS) was 53.3% (95% confidence interval (CI): 38.7?73.4) and overall survival (OS) was 77.8% (95% CI: 64.5?93.9). Seventeen patients (44%) relapsed with a median of 159 days (range 28?655) after CART-19 infusion. No difference in day 28 minimal residual disease negative complete response rate, 12-month OS/EFS, or incidence of CD19-positive or -negative relapses was observed among patients receiving InO before or after apheresis. Compared to published data for patients treated with CART-19 therapy without prior InO exposure, response and OS/EFS for patients treated with InO prior to CART-19 are similar.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Leukemia (2022)

Editorial: Nature Publishing Group

 Año de publicación: 2022

Tipo de publicación: Artículo de Revista

 DOI: h10.1038/s41375-022-01740-9

ISSN: 0887-6924,1476-5551

Url de la publicación: https://doi.org/10.1038/s41375-022-01740-9

Autoría

CEOLIN, VALERIA

BRIVIO, ERICA

TINTEREN, HARM VAN

RHEINGOLD, SUSAN R.

LEAHY, ALLISON

VORMOOR, BRITTA

O'BRIEN, MAUREEN M.

RUBINSTEIN, JEREMY D.

KALWAK, KRZYSZTOF

DE MOERLOOSE, BARBARA

JACOBY, ELAD

BADER, PETER

MONICA LOPEZ DUARTE

GOEMANS, BIANCA F.

LOCATELLI, FRANCO

HOOGERBRUGGE, PETER

CALKOEN, FRISO G.

ZWAAN, CHRISTIAN MICHEL