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 Detalle_Publicacion

Shiga toxin-B targeted gold nanorods for local photothermal treatment in oral cancer clinical samples

Abstract: Introduction A great challenge in nanomedicine, and more specifically in theranostics, is to improve the specificity, selectivity, and targeting of nanomaterials towards target tissues or cells. The topical use of nanomedicines as adjuvants to systemic chemotherapy can significantly improve the survival of patients affected by localized carcinomas, reducing the side effects of traditional drugs and preventing local recurrences. Methods Here, we have used the Shiga toxin, to design a safe, high-affinity protein-ligand (ShTxB) to bind the globotriaosylceramide receptor (GB3) that is overexpressed on the surfaces of preneoplastic and malignant cancer cells in the head and neck tumors. Results We find that ShTxB functionalized gold nanorods are efficiently retrotranslocated to the GB3-positive cell cytoplasms. After 3 minutes of laser radiation with a wavelength resonant with the AuNR longitudinal localized surface plasmon, the death of the targeted cancer cells is activated. Both preclinical murine models and patient biopsy cells show the non-cytotoxic nature of these functionalized nanoparticles before light activation and their treatment selectivity. Discussion These results show how the use of nanomedicines directed by natural ligands can represent an effective treatment for aggressive localized cancers, such as squamous cell carcinoma of the oral cavity.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: International Journal of Nanomedicine,2022,17, 5747-5760

Editorial: Dove Medical Press

 Fecha de publicación: 01/11/2022

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.2147/ijn.s381628

ISSN: 1178-2013,1176-9114

 Proyecto español: PGC2018- 101464-B-I00

Url de la publicación: https://doi.org/10.2147/ijn.s381628

Autoría

ELENA NAVARRO PALOMARES

GALÁN-VIDAL, J.

ALBERTO JOSE GANDARILLAS SOLINIS

SÁNCHEZ-IGLESIAS, A.

LIZ-MARZÁN, L. M.