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Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls

Abstract: Recent evidence indicates that DDR1 participates in myelination and that variants of DDR1 are associated with decreased cognitive processing speed (PS) in schizophrenia (SZ). Here, we explored whether DDR1 variants were associated with PS in subjects diagnosed with an early psychosis (EP), a condition often preceding SZ. Data from two Spanish independent samples (from Reus and Santander) including patients with EP (n = 75 and n = 312, respectively) and healthy controls (HCs; n = 57 and n = 160) were analyzed. The Trail Making Test part A was used to evaluate PS. Participants underwent genotyping to identify DDR1 variants rs1264323 and rs2267641. Cross-sectional data were analyzed with general linear models and longitudinal data were analyzed using mixed models. We examined the combined rs1264323AA-rs2267641AC/CC genotypes (an SZ-risk combination) on PS. The SZ-risk combined genotypes were associated with increased PS in EP patients but not in HCs in the cross-sectional analysis. In the longitudinal analysis, the SZ-risk combined genotypes were significantly associated with increased PS in both HCs and EP patients throughout the 10-year follow-up but no genotype × time interaction was observed. These results provide further evidence that DDR1 is involved in cognition and should be replicated with other samples.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Journal of Psychiatric Research, 2023, 158, 49-55

Editorial: Elsevier

 Año de publicación: 2023

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.jpsychires.2022.12.020

ISSN: 0022-3956,1879-1379

Url de la publicación: https://doi.org/10.1016/j.jpsychires.2022.12.020

Autoría

GAS, CINTA

MARIA ROSA AYESA ARRIOLA

BENEDICTO CRESPO FACORRO

GARCÍA-GAVILÁN, JESÚS

LABAD, JAVIER

MARTORELL, LOURDES

MUNTANÉ, GERARD

SANCHEZ-GISTAU, VANESSA

VILELLA, ELISABET