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Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

Abstract: Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules in the vasculopathy, as potential biomarkers of pulmonary fibrosis in RA-ILD+. Methods: We included 21 RA-ILD+ patients and two comparative groups: 25 RA-ILD- patients and 21 idiopathic pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined by ELISA, and mRNA expression was quantified by qPCR. Results: VCAM-1, MCP-1 and ADMA serum levels were increased in RA-ILD+ patients in relation to RA-ILD- and IPF patients. Additionally, RA-ILD+ patients exhibited increased CCL2 (gene encoding MCP-1) and decreased PRMT1 (gene related to ADMA synthesis) mRNA expression in relation to RA-ILD- patients. A lower expression of VCAM1, CCL2, and PRMT1 was observed in RA-ILD+ patients when compared with those with IPF. Furthermore, MCP-1 serum levels and PRMT1 mRNA expression were positively correlated with RA duration, and ADMA serum levels were positively associated with C-reactive protein in RA-ILD+ patients. Conclusion: Our study suggests that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify ILD in RA patients, as well as to discriminate RA-ILD+ from IPF, contributing to the early diagnosis of RA-ILD+.

 Autoría: Pulito-Cueto V., Remuzgo-Martínez S., Genre F., Atienza-Mateo B., Mora-Cuesta V.M., Iturbe-Fernández D., Lera-Gómez L., Sebastián Mora-Gil M., Prieto-Peña D., Portilla V., Blanco R., Corrales A., Ocejo-Vinyals J.G., Gualillo O., Ferraz-Amaro I., Cifrián J.M., López-Mejías R., González-Gay M.A.,

 Fuente: Frontiers in Molecular Biosciences, 2022, 19(9), 1056121

Editorial: Frontiers Media

 Año de publicación: 2022

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fmolb.2022.1056121

ISSN: 2296-889X

Url de la publicación: https://www.doi.org/10.3389/fmolb.2022.1056121

Autoría

PULITO-CUETO, VERÓNICA

REMUZGO-MARTÍNEZ, SARA

GENRE, FERNANDA

BELÉN ATIENZA MATEO

MORA-CUESTA, VÍCTOR M

DAVID ITURBE FERNANDEZ

LERA-GÓMEZ, LETICIA

SEBASTIÁN MORA-GIL, MARÍA

DIANA PRIETO PEÑA

PORTILLA, VIRGINIA

CORRALES, ALFONSO

OCEJO-VINYALS, J GONZALO

GUALILLO, ORESTE

FERRAZ-AMARO, IVÁN

LÓPEZ-MEJÍAS, RAQUEL