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Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA schizophrenia consortium

Abstract: Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.

 Fuente: Molecular Psychiatry, 2022, 28, 1201-1209

Editorial: Nature Publishing Group

 Fecha de publicación: 01/12/2022

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41380-022-01897-w

ISSN: 1359-4184,1476-5578

Url de la publicación: https://doi.org/10.1038/s41380-022-01897-w

Autores/as

CONSTANTINIDES, CONSTANTINOS

HAN, LAURA K. M.

ALLOZA, CLARA

ANTONUCCI, LINDA ANTONELLA

ARANGO, CELSO

MARIA ROSA AYESA ARRIOLA

BANAJ, NERISA

BERTOLINO, ALESSANDRO

BORGWARDT, STEFAN

BRUGGEMANN, JASON

BUSTILLO, JUAN

BYKHOVSKI, OLEG

CALHOUN, VINCE

CARR, VAUGHAN

CATTS, STANLEY

CHUNG, YOUNG-CHUL

COVADONGA MARTINEZ DIAZ-CANEJA

RAYMOND SALVADOR CIVIL

DIANA TORDESILLAS GUTIERREZ