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Effect of DISC1 polymorphisms on the long-term course of neurocognitive deficits in non-affective psychosis

Abstract: Neurocognitive deficits are core symptoms of schizophrenia that determine a poorer outcome. High variability in the progression of neuropsychological deficits in schizophrenia has been described. It is still unknown whether genetic variations can affect the course of cognitive deficits. Variations in the Disrupted in Schizophrenia 1 (DISC1) gene have previously been associated with neurocognitive deficits. This study investigated the association between 3 DISC1 polymorphisms (rs6675281 (Leu607Phe), rs1000731, and rs821616 (Ser704Cys)) and long-term (3 years) cognitive performance. One-hundred-thirty-three Caucasian drug-naive patients experiencing a first episode of non-affective psychosis were genotyped. Cognitive function was assessed at baseline and after 3 years of initiating treatment. Other clinical and socio-demographic variables were recorded to eliminate potential confounding effects. Patients carrying the A allele of rs1000731 exhibited a significant improvement in Working Memory and Attention domains, and the homozygosity of the A allele of rs821616 showed a significant improvement in Motor Dexterity performance over 3 years of follow-up. In conclusion, DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis.

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 Fuente: European Psychiatry : the Journal of the Association of European Psychiatrists, 2015, 30(7), 861-867

Editorial: Elsevier

 Año de publicación: 2015

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.eurpsy.2015.07.007

ISSN: 0924-9338,1778-3585

Proyecto español: FIS 00/3095, 03/1009, PI06/0507