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 Detalle_Publicacion

Falls predict acute hospitalization in Parkinson's disease

Abstract: Background: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission. Objective: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. Methods: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. Results: Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH. Conclusion: Falls is an independent predictor of AH in PD patients.

 Fuente: Journal of Parkinson's disease, 2023, 13(1), 105-124

Editorial: IOS Press

 Año de publicación: 2023

Nº de páginas: 20

Tipo de publicación: Artículo de Revista

 DOI: 10.3233/JPD-212539

ISSN: 1877-7171,1877-718X

Url de la publicación: https://www.doi.org/10.3233/JPD-212539

Autoría

SANTOS GARCÍA, DIEGO

DE DEUS FONTICOBA, TERESA

CORES, CARLOS

SUÁREZ CASTRO, ESTER

HERNÁNDEZ VARA, JORGE

JESÚS, SILVIA

MIR, PABLO

COSGAYA, MARINA

JOSÉ MARTÍ, MARIA

PASTOR, PAU

CABO, IRIA

SEIJO, MANUEL

LEGARDA, INÉS

VIVES, BÁRBARA

CABALLOL, NURIA

RÚIZ MARTÍNEZ, JAVIER

CROITORU, IOANA

CUBO, ESTHER

MIRANDA, JAVIER