Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Analysis of serum proteome after treatment of osteoporosis with anabolic or antiresorptive drugs

Abstract: The aim of the study was to explore new markers in serum proteome associated with the response to antiosteoporosis drugs, namely teriparatide and denosumab. We obtained serum samples from 14 patients with osteoporosis, both at baseline and after 6 months of treatment with teriparatide (n = 10) or denosumab (n = 4). Samples were analyzed by nanoliquid chromatography coupled to high-resolution mass spectrometry on a QTOF 5600 (SCIEX) apparatus. The spectrometry data were analyzed with Mascot against the UniProtKB base and then several quality-control filters were applied for the identification of peptides (false discovery rate, FDR q < 0.02) and their quantification (FDR q < 0.05). In the group treated with teriparatide, 28 proteins were identified with significant differences before and after treatment. A pathway analysis by using the Reactome database revealed significant enrichment in the Insulin Like Growth Factor 1 (IGF-I) (FDR q 4 × 10?2) and innate immune system (FDR q 2 × 10?3) pathways. Among patients treated with denosumab, we observed significant differences in the levels of 10 proteins, which were also enriched in the pathways related to the innate immune system (FDR q 3 × 10?2). These results suggest that the innate immune system may be involved in the response to antiosteoporosis drugs.

 Fuente: Metabolites 2022, 12, 399

Editorial: Multidisciplinary Digital Publishing Institute (MDPI)

 Año de publicación: 2022

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/metabo12050399

ISSN: 2218-1989

Autores/as

CIORDIA, SERGIO

MARIA CAROLINA SAÑUDO CAMPO

ROA-BAUTISTA, ADRIEL

OCEJO-VIÑALS, JAVIER G.

CORRALES, FERNANDO