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Nanoparticle biocoating to create ATP-powered swimmers capable of repairing proteins on the fly

Abstract: In this study, we combine nanotechnology and biotechnology to design a biocompatible propulsion system based on the molecular chaperone Hsp90, a heat-shock protein (Hsp) that, in the presence of adenosine 5'-triphosphate (ATP), undergoes nanoscale conformational changes while trapping and renaturing other proteins. We show how, subjected to ATP availability in the medium, Hsp90-functionalized particles significantly enhance their diffusion motion, being able to achieve ballistic motion, while keeping the ability to restore the activity of surrounding heat-inactivated proteins. This biomechanics-based propulsion mechanism represents a promising strategy for the design of self-propelled nanodevices capable of performing sophisticated tasks in live biological contexts that include sensing the environment, recognizing and capturing, folding, and restoring defective proteins on the fly. In the short term, Hsp90-driven nanodevices could be applied to improve industrial processes that require enzymatic catalysis and high temperatures. But in the medium to long term, this bioactive coating could be used in the design of nanomachines that, like mini-robots, navigate the complex body cavities of biological tissues, deliver therapies and/or remove misfolded proteins in disorders such as Alzheimer's or Parkinson's disease.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Rodríguez-Ramos A., Ramos-Docampo M.A., Salgueiriño V., Fanarraga M.L.,

 Fuente: Materials Today Advances, 2023, 17, 100353

 Año de publicación: 2023

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.mtadv.2023.100353

ISSN: 2590-0498

Proyecto español: PID2020-119242RB-I00

Url de la publicación: https://doi.org/10.1016/j.mtadv.2023.100353