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Vascular endothelial growth factor and its soluble receptor in systemic lupus erythematosus patients

Abstract: Vascular endothelial growth factor (VEGF) is a major regulator of physiological and pathological angiogenesis. Its soluble receptor (sVEGFR) is a potent VEGF antagonist. Systemic lupus erythematosus (SLE) is an autoimmune disease with a diverse array of clinical manifestations that affect virtually any organ. We aimed to analyze the relationship of VEGF and sVEGFR with SLE disease-related features including disease activity, damage, and severity. Serum levels of VEGF165 isoform and sVEGFR (receptor 1) were assessed in 284 well-characterized patients with SLE. Linear regression analysis was performed to analyze the relationship of disease characteristics with both VEGF and sVEGFR. Patients with a disease damage index (SLICC score) equal to or greater than 1 had significantly elevated serum levels of VEGF and sVEGFR. Regarding disease-specific features, musculoskeletal manifestations were the disease feature most commonly associated with the upregulation of both VEGF and sVEGFR. SLE disease damage is associated with higher levels of VEGF and sVEGFR.

 Autoría: Fuensanta Gómez-Bernal, Yolanda Fernández-Cladera, Juan Carlos Quevedo-Abeledo, María García-González, Agustín F. González-Rivera, Antonia de Vera-González, Candelaria Martín-González, Miguel Á. González-Gay and Iván Ferraz-Amaro

 Fuente: Biomolecules, 2022, 12(12), 1884

 Editorial: MDPI

 Fecha de publicación: 15/12/2022

 Nº de páginas: 10

 Tipo de publicación: Artículo de Revista

 DOI: 10.3390/biom12121884

 ISSN: 2218-273X

 Proyecto español: I.F-A

 Url de la publicación: https://doi.org/10.3390/biom12121884

Autoría

GÓMEZ-BERNAL, FUENSANTA

FERNÁNDEZ-CLADERA, YOLANDA

QUEVEDO-ABELEDO, JUAN CARLOS

GARCÍA-GONZÁLEZ, MARÍA

GONZÁLEZ-RIVERO, AGUSTÍN F.

VERA-GONZÁLEZ, ANTONIA DE

MARTÍN-GONZÁLEZ, CANDELARIA

FERRAZ-AMARO, IVÁN