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Angiogenic T Cells: potential biomarkers for the early diagnosis of interstitial lung disease in autoimmune diseases?

Abstract: Background: We explored, for the first time, the contribution of angiogenic T cells (TAng) in interstitial lung disease associated to autoimmune disease (AD-ILD+) as potential biomarkers of the disease, evaluating their role in the underlying vasculopathy and lung fibrosis. Additionally, the relationship of TAng with clinical manifestations and cellular and molecular endothelial dysfunctionrelated biomarkers was assessed. (2) Methods: We included 57 AD-ILD+ patients (21 with rheumatoid arthritis (RA)-ILD+, 21 with systemic sclerosis (SSc)-ILD+ and 15 with other AD-ILD+) and three comparative groups: 45 AD-ILD-- patients (25 RA-ILD-- and 20 SSc-ILD--); 21 idiopathic pulmonary fibrosis (IPF) patients; 21 healthy controls (HC). TAng were considered as CD3+CD184+CD31+ by flow cytometry. (3) Results: A similar TAng frequency was found between AD-ILD+ and IPF, being in both cases lower than that observed in AD-ILD- and HC. A lower TAng frequency was associated with negative Scl-70 status and lower FEV1/FVC ratio in SSc-ILD+, as well as with men in RA-ILD+ and non-specific interstitial pneumonia radiological pattern in other AD-ILD+. No relationship between TAng and endothelial progenitor cells, endothelial cells and vascular endothelial growth factor gene expression and protein levels was disclosed. (4) Conclusions: Our findings suggest TAng as potential biomarkers for the early diagnosis of ILD in AD.

 Autoría: Verónica Pulito-Cueto, Sara Remuzgo-Martínez, Fernanda Genre, Belén Atienza-Mateo, Víctor M. Mora-Cuesta, David Iturbe-Fernández, Leticia Lera-Gómez, Javier Rodriguez-Carrio, Diana Prieto-Peña, Virginia Portilla, Ricardo Blanco, Alfonso Corrales, Oreste Gualillo, José M. Cifrián, Raquel López-Mejías and Miguel A. González-Gay

 Fuente: Biomedicines, 2022, 10(4), 851

 Editorial: MDPI AG

 Año de publicación: 2022

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.3390/biomedicines10040851

 ISSN: 2227-9059

 Url de la publicación: https://doi.org/ 10.3390/biomedicines10040851

Autoría

PULITO-CUETO, VERÓNICA

REMUZGO-MARTÍNEZ, SARA

GENRE, FERNANDA

ATIENZA-MATEO, BELÉN

MORA-CUESTA, VÍCTOR M.

ITURBE-FERNÁNDEZ, DAVID

LERA-GÓMEZ, LETICIA

RODRIGUEZ -CARRIO, JAVIER

PRIETO-PEÑA, DIANA

PORTILLA, VIRGINIA

BLANCO, RICARDO

CORRALES, ALFONSO

GUALILLO, ORESTE

CIFRIÁN, JOSÉ M.

LÓPEZ-MEJÍAS, RAQUEL