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Infective endocarditis in diabetic patients: a different profile with prognostic consequences

Abstract: Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008?2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0  15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16-1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21?1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06?1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26?2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: María Isabel Biezma, Patricia Muñoz, Sofía De la Villa, Mª Carmen Fariñas-Álvarez, Francisco Arnáiz de las Revillas, Encarnación Gutierrez-Carretero, Arístides De Alarcón, Raquel Rodríguez-García, Jaume Llopis, Miguel Ángel Goenaga, Andrea Gutierrez-Villanueva, Antonio Plata, Laura Vidal, Manuel Martínez-Sellés and on behalf of GAMES

 Fuente: Journal of Clinical Medicine 2022, 11, 2651

Editorial: MDPI

 Año de publicación: 2022

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm11092651

ISSN: 2077-0383

Url de la publicación: https://doi.org/10.3390/ jcm11092651

Autores/as

BIEZMA, MARÍA ISABEL

MUÑOZ, PATRICIA

VILLA, SOFÍA DE LA

GUTIERREZ-CARRETERO, ENCARNACIÓN

ALARCÓN, ARÍSTIDES DE

RODRÍGUEZ-GARCÍA, RAQUEL

LLOPIS, JAUME

GOENAGA, MIGUEL ÁNGEL

GUTIERREZ-VILLANUEVA, ANDREA

PLATA, ANTONIO

VIDAL, LAURA

MARTÍNEZ-SELLÉS, MANUEL

GAMES