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Longitudinal trajectories in negative symptoms and changes in brain cortical thickness: 10-year follow-up study

Abstract: Background Understanding the evolution of negative symptoms in first-episode psychosis (FEP) requires long-term longitudinal study designs that capture the progression of this condition and the associated brain changes. Aims To explore the factors underlying negative symptoms and their association with long-term abnormal brain trajectories. Method We followed up 357 people with FEP over a 10-year period. Factor analyses were conducted to explore negative symptom dimensionality. Latent growth mixture modelling (LGMM) was used to identify the latent classes. Analysis of variance (ANOVA) was conducted to investigate developmental trajectories of cortical thickness. Finally, the resulting ANOVA maps were correlated with a wide set of regional molecular profiles derived from public databases. Results Three trajectories (stable, decreasing and increasing) were found in each of the three factors (expressivity, experiential and attention) identified by the factor analyses. Patients with an increasing trajectory in the expressivity factor showed cortical thinning in caudal middle frontal, pars triangularis, rostral middle frontal and superior frontal regions from the third to the tenth year after the onset of the psychotic disorder. The F-statistic map of cortical thickness expressivity differences was associated with a receptor density map derived from positron emission tomography data. Conclusions Stable and decreasing were the most common trajectories. Additionally, cortical thickness abnormalities found at relatively late stages of FEP onset could be exploited as a biomarker of poor symptom outcome in the expressivity dimension. Finally, the brain areas with less density of receptors spatially overlap areas that discriminate the trajectories of the expressivity dimension.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: British Journal of Psychiatry, 2023, 223, 309-318

Editorial: Cambridge University Press

 Año de publicación: 2023

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1192/bjp.2022.192

ISSN: 0007-1250,1472-1465

Url de la publicación: https://doi.org/10.1192/bjp.2022.192

Autoría

CANAL-RIVERO, MANUEL

RUIZ-VEGUILLA, MIGUEL

VICTOR ORTIZ GARCIA DE LA FOZ

LÓPEZ-DÍAZ, ÁLVARO

GARRIDO-TORRES, NATHALIA

MARIA ROSA AYESA ARRIOLA

MAYORAL-VAN SON, JACQUELINE

BRAMBILLA, PAOLO

KIRCHER, TILO

ROMERO-GARCÍA, RAFAEL

BENEDICTO CRESPO FACORRO