Abstract: Proper gastric distention with oral contrast agents is a well-recognized CT technique for imaging of the stomach. We present the basal and after water ingestion F-FDG PET/CT images that show abnormal focal FDG uptake in a clinically unsuspected gastric relapse of mantle-cell lymphoma. The patient had achieved complete remission after chemoradiotherapy and autologous stem-cell transplantation 3 years before. The images obtained after the distention of the stomach with water were crucial to confirm the presence of an FDG-avid lesion in the antrum and to distinguish between physiological and pathological radiotracer uptake. Histological analysis confirmed mantle-cell lymphoma infiltration.

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