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Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients

Abstract: In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46?0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38?0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18?2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: American Journal of Transplantation, 2015, 15(5), 1323-1335

Editorial: Wiley Periodicals Inc.

 Año de publicación: 2015

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/ajt.13107

ISSN: 1600-6135,1600-6143

Url de la publicación: https://doi.org/10.1111/ajt.13107

Autores/as

FERNÁNDEZ-RUIZ, M.

CORRALES, I.

GIMÉNEZ, E.

CRESPO, J.

LÓPEZ-OLIVA, M. O.

BENEYTO, I.

MARTÍN-MORENO, P. L.

LLAMAS-FUENTE, F.

GUTIÉRREZ, A.

GARCÍA-ALVAREZ, T.

GUERRA-RODRÍGUEZ, R.

CALVO, N.

FERNÁNDEZ-RODRÍGUEZ, A.

TABERNERO-ROMO, J. M.

NAVARRO, M. D.

RAMOS-VERDE, A.

AGUADO, J. M.

NAVARRO, D.