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Role of rs1343151 IL23R and rs3790567 IL12RB2 polymorphisms in biopsy-proven giant cell arteritis

Abstract: Objective.To assess the potential association between the rs1343151 IL23R and the rs3790567 IL12RB2 polymorphisms and giant cell arteritis (GCA). We also studied whether these polymorphisms might influence the phenotypic expression of GCA. Methods.In total, 357 Spanish patients with biopsy-proven GCA and 574 matched controls were assessed. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the rs1343151 IL23R and the rs3790567 IL12RB2 polymorphisms using a predesigned TaqMan allele discrimination assay and by polymerase chain reaction amplification. Results.Regarding the rs1343151 IL23R polymorphism, no significant differences in the genotype or allele frequencies between GCA patients and healthy controls were observed. The frequency of the minor allele A of the rs3790567 IL12RB2 variant was increased in GCA patients compared with controls (30.1% vs 25.7%, respectively; p = 0.039, OR 1.25, 95% CI 1.01?1.54). An increased frequency of subjects carrying the minor allele A (GA+AA genotypes) of the rs3790567 IL12RB2 polymorphism was found among GCA patients compared with controls (52.8% vs 44.4%; p = 0.013, OR 1.40, 95% CI 1.06?1.85). Although a higher frequency of the combination of minor alleles (A-A) in the subgroup of patients with visual ischemic complications compared with the combination of both major alleles (G-G; p = 0.029) or with the other allelic combinations (p = 0.035) was found, logistic regression analysis showed that this association was no longer significant after adjustment for potential confounding factors (A-A vs G-G: OR 2.10, 95% CI 0.88?5.04, p = 0.096). Conclusion.Our results support a potential influence of the rs3790567 IL12RB2 polymorphism in the pathogenesis of GCA.

 Autoría: Rodríguez-Rodríguez L., Carmona F.D., Castañeda S., Miranda-Filloy J.A., Morado I.C., Narváez J., Marí-Alfonso B., Gómez-Vaquero C., Amigo-Díaz E., Ríos-Fernández R., Blanco R., Llorca J., Fernández-Gutiérrez B., Martín J., González-Gay M.A.,

 Fuente: The Journal of Rheumatology, 2011, 38, 5

 Editorial: The Journal of Rheumatology Publishing Company Limited

 Año de publicación: 2011

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.101046

 ISSN: 0315-162X

 Url de la publicación: https://doi.org/10.3899/jrheum.101046

Autoría

RODRÍGUEZ-RODRÍGUEZ, LUIS

CARMONA, FRANCISCO

CASTAÑEDA, SANTOS

MIRANDA-FILLOY, JOSÉ A.

MORADO, INMACULADA

NARVÁEZ, JAVIER

MARÍ-ALFONSO, BEATRIZ

GÓMEZ-VAQUERO, CARMEN

AMIGO-DÍAZ, ENCARNACIÓN

RÍOS-FERNÁNDEZ, RAQUEL

FRANCISCO JAVIER LLORCA DIAZ

FERNÁNDEZ-GUTIÉRREZ, BENJAMÍN

MARTÍN, JAVIER