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Comparison of metabolic effects of aripiprazole, quetiapine and ziprasidone after 12 weeks of treatment in first treated episode of psychosis

Abstract: This randomized open-label study compared the incidence of metabolic side effects of aripiprazole, ziprasidone and quetiapine in a population of medication-naïve first-episode psychosis patients. A total of 202 subjects were enrolled. Body weight, body mass index, leptin, fasting lipids and fasting glycaemic parameters were measured at baseline and at 3 months follow-up. A hundred and sixty-six patients completed the follow-up and were included in the analyses. A high proportion of patients experienced a significant weight increase (>7% of their baseline weight): 23% ziprasidone (n=12), 32% with quetiapine (n=16) and 45% with aripiprazole (n=31). Patients treated with aripiprazole gained significantly more weight than the patients in the ziprasidone group (1.2 kg [SD=4.1] versus 4.3 kg [SD=4.8], respectively). The increase in leptin levels was greater in women treated with aripiprazole than in those treated with ziprasidone (p=0.030). Mean prolactin levels significantly increased in patients treated with quetiapine and ziprasidone but not in those treated with aripiprazole. Patients treated with quetiapine and aripiprazole showed a significant increase in total cholesterol and LDL-cholesterol plasma levels. Quetiapine-treated patients resulted in a higher increase in LDL-cholesterol than patients treated with ziprasidone (p=0.021). No other significant differences between groups were found. No significant changes in glycaemic parameters were observed. Our results suggest that ziprasidone has a lower liability for inducing weight gain and lipid abnormalities than aripiprazole or quetiapine

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Schizophrenia Research, 2014, 159(1), 90-94

Editorial: Elsevier

 Año de publicación: 2014

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.schres.2014.07.045

ISSN: 0920-9964,1573-2509

Url de la publicación: https://doi.org/10.1016/j.schres.2014.07.045

Autoría

ROCIO PEREZ IGLESIAS

ORTÍZ GARCIA DE LA FOZ, VICTOR

OBDULIA MARTINEZ GARCIA

JOSE ANTONIO AMADO SEÑARIS

MARIA TERESA GARCIA UNZUETA

MARIA ROSA AYESA ARRIOLA

RAFAEL TABARES SEISDEDOS

BENEDICTO CRESPO FACORRO