Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

First description and validation of a new method for estimating aortic stenosis burden and predicting the functional response to TAVI

Abstract: Background: Up to one-fifth of patients continue to have poor quality of life after transcatheter aortic valve implantation (TAVI), with an additional similar proportion not surviving 1 year after the procedure. We aimed to assess the value of a new method based on an integrated analysis of left ventricular outflow tract flow velocity and aortic pressure to predict objective functional improvement and prognosis after TAVI. Methods: In a cohort of consecutive patients undergoing TAVI, flow velocity-pressure integrated analysis was obtained from simultaneous pressure recordings in the ascending aorta and flow velocity recordings in the left ventricular outflow tract by echocardiography. Objective functional improvement 6 months after TAVI was assessed through changes in a 6-min walk test and NT-proBNP levels. A clinical follow-up was conducted at 2 years. Results: Of the 102 patients studied, 82 (80.4%) showed objective functional improvement. The 2-year mortality of these patients was significantly lower (9% vs. 44%, p=?0.001). In multivariate analysis, parameter "(Pressure at Vmax - Pressure at Vo)/Vmax" was found to be an independent predictor for objective improvement. The C-statistic was 0.70 in the overall population and 0.78 in the low-gradient subgroup. All echocardiographic parameters and the valvuloarterial impedance showed a C-statistic of <0.6 for the overall and low-gradient patients. In a validation cohort of 119 patients, the C-statistic was 0.67 for the total cohort and 0.76 for the low-gradient subgroup. Conclusion: This new method allows predicting objective functional improvement after TAVI more precisely than the conventional parameters used to assess the severity of aortic stenosis, particularly in low-gradient patients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: de la Torre Hernandez J.M., Veiga Fernandez G., Ben-Assa E., Iribarren J., Sainz Laso F., Lee D.H., Ruisanchez Villar C., Lerena P., Garcia Camarero T., Iribarren Sarrias J.L., Cuesta Cosgaya J.M., Maza Fernandez M.E., Garilleti C., Fradejas-Sastre V., Benito M., Barrera S., Gil Ongay A., Vazquez de Prada J.A., Zueco J.,

 Fuente: Frontiers in Cardiovascular Medicine, 2023, 10, 1215826

Editorial: Frontiers Media S.A.

 Año de publicación: 2023

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fcvm.2023.1215826

ISSN: 2297-055X

Url de la publicación: https://doi.org/10.3389/fcvm.2023.1215826

Autoría

VEIGA FERNÁNDEZ, GABRIELA

BEN-ASSA, EYAL

IRIBARREN, JULIA

SAINZ LASO, FERMÍN

LEE, DAE-HYUN

RUISÁNCHEZ VILLAR, CRISTINA

LERENA, PIEDAD

GARCÍA CAMARERO, TAMARA

IRIBARREN SARRIAS, JOSÉ L.

CUESTA COSGAYA, M.

GARILLETI, CELIA

FRADEJAS-SASTRE, VÍCTOR

BENITO, MERCEDES

BARRERA, SERGIO

ZUECO, JAVIER