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The crosstalk between hypoxia and innate immunity in the development of obesity-related nonalcoholic fatty liver disease

Abstract: Nonalcoholic fatty liver disease (NAFLD) has become a major health issue in western countries in parallel with the dramatic increase in the prevalence of obesity and all obesity related conditions, including respiratory diseases as obstructive sleep apneahypopnea syndrome (OSAHS). Interestingly, the severity of the liver damage in obesity-relatedNAFLD has been associatedwith the concomitant presence of OSAHS. In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis,may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NF????.Thus, the severity of liver involvement in obese NAFLD patients with a concomitant diagnosis of OSAHS could be explained. In this review, we focus on the molecularmechanisms underlying the hepatic response to chronic intermittent hypoxia and its interaction with innate immunity in obesity-related NAFLD.

 Fuente: BioMed Research International, 2015, 319745

 Editorial: Hindawi Publishing Corporation

 Año de publicación: 2015

 Nº de páginas: 8

 Tipo de publicación: Artículo de Revista

 DOI: 10.1155/2015/319745

 ISSN: 2314-6133,2314-6141