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Abstract: Nonalcoholic fatty liver disease (NAFLD) has become a major health issue in western countries in parallel with the dramatic increase in the prevalence of obesity and all obesity related conditions, including respiratory diseases as obstructive sleep apneahypopnea syndrome (OSAHS). Interestingly, the severity of the liver damage in obesity-relatedNAFLD has been associatedwith the concomitant presence of OSAHS. In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis,may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NF????.Thus, the severity of liver involvement in obese NAFLD patients with a concomitant diagnosis of OSAHS could be explained. In this review, we focus on the molecularmechanisms underlying the hepatic response to chronic intermittent hypoxia and its interaction with innate immunity in obesity-related NAFLD.
Fuente: BioMed Research International, vol. 2015, Article ID 319745
Editorial: Hindawi Publishing Corporation
Año de publicación: 2015
Nº de páginas: 8
Tipo de publicación: Artículo de Revista
DOI: 10.1155/2015/319745
ISSN: 2314-6133,2314-6141
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MARIA TERESA ARIAS LOSTE
EMILIO FABREGA GARCIA
MARCOS LOPEZ HOYOS
JAVIER CRESPO GARCIA
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