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Vascular endothelial growth factor-delivery systems for cardiac repair: an overview

Abstract: Since the discovery of the Vascular Endothelial Growth Factor (VEGF) and its leading role in the angiogenic process, this has been seen as a promising molecule for promoting neovas-cularization in the infarcted heart. However, even though several clinical trials were initiated, no therapeutic effects were observed, due in part to the short half life of this factor when administered directly to the tissue. In this context, drug delivery systems appear to offer a promising strategy to overcome limitations in clinical trials of VEGF. The aim of this paper is to review the principal drug delivery systems that have been de-veloped to administer VEGF in cardiovascular disease. Studies published in the last 5 years are reviewed and the main features of these systems are explained. The tissue engineering concept is introduced as a therapeutic alternative that holds promise for the near future.

 Fuente: Theranostics, 2012, 2(6), 541-552

 Editorial: Ivyspring International Publisher

 Año de publicación: 2012

 Nº de páginas: 12

 Tipo de publicación: Artículo de Revista

 DOI: 10.7150/thno.3682

 ISSN: 1838-7640

 Proyecto español: PSS 0100000-2008-1

 Url de la publicación: https://doi.org/10.7150/thno.3682

Autoría

SIMÓN-YARZA, TERESA

FORMIGA, FABIO R.

PELACHO, BEATRIZ

PROSPER, FELIPE

BLANCO-PRIETO, MARÍA J.