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Abstract: Background. Prognostic biomarkers of acute rejection (AR) in solid organ transplantation have been addressed in multiple small retrospective studies, and there is a critical need for multicenter studies. Because of their tolerogenic properties, regulatory T cells (Tregs) play an important role in transplant outcome. Methods. In the present multicenter study, we have retrospectively examined different Treg subpopulations in an independent cohort of kidney transplant patients within first year after kidney transplantation. All participating centers used identical flow cytometry standard operating procedures. Results. Seventy-five renal transplant patients were included, and six of them experienced an AR episode. The activated Treg (aTreg) subpopulation (CD4+CD25highCD62L+CD45RO+) was increased in the AR group before transplantation, and an aTreg percentage higher than 1.46% before kidney transplantation conferred an increased risk of AR. The univariate logistic regression model achieved an area under the curve of 81.6%. By including recipient age and thymoglobulin induction as variables in a multivariate logistic regression model, the prediction of AR improved to 92.4%.
Fuente: Transplantation, 2014, 98(11), 1213-1218
Editorial: Lippincott Williams & Wilkins
Fecha de publicación: 15/12/2014
Nº de páginas: 6
Tipo de publicación: Artículo de Revista
DOI: 10.1097/TP.0000000000000202
ISSN: 0041-1337,1534-6080
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DAVID SAN SEGUNDO ARRIBAS
MILLÁN, OLGA
MUÑOZ CACHO, PEDRO
BOIX, FRANCISCO
PAZ ARTAL, ESTELA
TALAYERO, PALOMA
MORALES, JOSÉ MARÍA
MURO, MANUEL
MARIA DE LOS ANGELES DE COS COSSIO
GUIRADO, LLUIS
LLORENTE, SANTIAGO
PASCUAL, JULIO
ARIAS, MANUEL
BRUNET, MERCÉ
MARCOS LOPEZ HOYOS
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