Abstract: Background: Nursing students suffer high levels of stress, especially in the first year.
Objectives: to compare academic stress at the beginning and end of nursing studies; to analyse the relationships between academic stress, mental health, and protective factors; and to examine whether resilience mitigates the effect of academic stress on psychological well-being.
Design: A cross-sectional study.
Setting and participants: Sample was 370 first- and fourth-year nursing students from Spain (University of Castilla-La Mancha, University of Cantabria, and University of Sevilla).
Variables and data collection: We assessed academic and clinical stress, coping skills, anxiety, depression, psychological well-being, and resilience were measured.
Data analysis: We performed a descriptive analysis of the study sample, as well as correlation and hierarchical regression models. Additionally, mediation models were estimated.
Results: First-year students presented higher academic stress than fourth-year students. Clinical stress, anxiety, depression, and emotional coping predicted academic stress, while academic stress, depression, and coping skills predicted psychological well-being. Mediation models showed a significant path between academic stress, resilience, depression, and psychological well-being.
Conclusion: Academic stress has a detrimental effect on the mental health. Coping strategies and resilience may be protective factors that should be encouraged in interventions designed to improve psychological well-being.
Keywords: Mental health; Nursing students; Psychological well-being; Resilience; Stress.