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Metabolic biomarkers in obese community-dwelling children: NANOS study

Abstract: Introduction: Obesity and obstructive sleep apnea syndrome in children have been strongly and independently associated with metabolic and cardiovascular morbidities. Aim: To evaluate the presence of metabolic alterations among obese children recruited from the community. Methods: A cross-sectional, prospective multicenter study of Spanish children aged 3 ? 14 years-old with a body mass index (BMI)? 95th percentile for age and sex were randomly selected in the first phase of this study. Four groups were obtained for follow-up:(1) No treatment; (2) Dietary intervention; (3) surgical treatment of OSA; (4) CPAP treatment of OSA. We performed fasting blood tests at baseline (T0) and ?1-year follow-up after the intervention (T1). Results: 113 obese children with a mean age of 11.3±2.9 years completed T0 and T1 assessments within 11.8±4.1 months. Their mean BMI at T0 was 27.6±4.7 kg/m2, and mean respiratory disturbance index was 8.56±12.97 at T0 and 3.29 ± 3.99/hr TST at T1. Significant univariate associations between BMI and C reactive protein (CRP), insulin and HOMA emerged at both T0 and T1 for the whole cohort. To assess potential metabolic characteristics that independently associated with OSA incidence, OSA persistence, or residual OSA, stepwise logisitc regression models were performed, but did not reach statistical significance. However, HOMA index was a predictor of incident (OR: 1.97) and persistent OSA (OR:1.10), while CRP emerged as a predictor of residual OSA (OR:1.41). Conclusions: (1) Concurrent obesity and OSA promotes metabolic and inflammatory alterations. (2) Specific metabolic alterations appear to behave as predictors of incident, persistent and residual OSA in obese children. Funded by SEPAR.

Otras comunicaciones del congreso o articulos relacionados con autores/as de la Universidad de Cantabria

 Editorial: European Respiratory Society

 Año de publicación: 2016

 Nº de páginas: 1

 Tipo de publicación: Comunicación a Congreso

 DOI: 10.1183/13993003.congress-2016.PA373

 ISSN: 0903-1936,1399-3003

 Url de la publicación: https://doi.org/0.1183/13993003.congress-2016.PA373

Autoría

ALONSO ÁLVAREZ, MARÍA LUZ

TERÁN-SANTOS, JOAQUÍN

CORDERO-GUEVARA, JOSÉ

JURADO-LUQUE, MARÍA JOSÉ

CORRAL-PEÑAFIEL, JAIME

DURÁN-CANTOLLA, JOAQUÌN

MASA-JIMÉNEZ JUAN FERNANDO

KHEIRANDISH-GOZAL, LEILA

GOZAL, DAVID