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Abstract: To determine if polygraphic variables (PV) are associated with optic nerve dysfunction (OND) in obstructive sleep apnoea-hypopnoea syndrome (OSAHS).Prospective cohort of OSAHS with CPAP. Patients undertook an initial optical coherence tomography (OCT) to measure their baseline Bruch?s membrane opening-minimum rim width (BMO-MRW).OCTs were repeated during the follow-up. Demographic and anthropometric variables were recorded and cardiovascular comorbidities, Epworth Sleepiness Scale(ESS)score and the PV:AHI,cumulative time percentage with oxygen saturation<90%(CT90) and SpO2.Logistic regression analysis was carried out with BMO-MRW as the dependent variable and AHI and nocturnal respiratory failure (NRF) as the independent variables, where NRF was:CT90?30 orSpO2?90%.36 patients (58.3% male,59.42years,mean BMI34.39).The most common comorbidity was hypertension (61%),followed by dyslipidaemia (44%),DM (25%).The mean AHI was 46.30± 9.08, mean CT90 10.25±5.97 and mean SpO292%. Mean ESSscore 9.83±3.94.Univariate analysis revealed NRF to be the sole predictive factor of OND in OSAHS (p=0.049), with a relative risk almost three times higher compared to controls (RR=2.78). However,multivariate analysis did not show NRF to have a statistically significant association (p=0.066)with OND, despite an even higher RR of 5.6.AHI didn´t demonstrate any association with OND(p=0.448,RR=0.99).The only statistically significant predictive factor from multivariate analysis was DM(p=0.023, RR=5.6).NRF may be the main polysgraphic variable linked to OND in OSAHS. Patients with NRF have approximately 5.6 times higher risk,with a p-value very close to statistical significance.This study was limited by the very small sample size.
Editorial: European Respiratory Society
Año de publicación: 2020
Nº de páginas: 1
Tipo de publicación: Comunicación a Congreso
DOI: 10.1183/13993003.congress-2020.2526
ISSN: 0903-1936,1399-3003
Url de la publicación: https://doi.org/10.1183/13993003.congress-2020.2526
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TERESA DIAZ DE TERAN LOPEZ
MONICA GONZALEZ MARTINEZ
CASADO, ALFONOSO
NEBOT, CLAUDIA
LEE, KIMBERLEY
LÓPEZ DE EGUILETA, ALICIA
ESCOBAR, FABIOLA
CABELLO, MARTA
RUIZ, JUAN JOSÉ
MARTÍNEZ, MARIÁN
FONSECA, SORAYA
QUEIPO, CARLOS
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