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Systemic inflammation differences in brain-vs. circulatory-dead donors: impact on lung transplant recipients

Abstract: Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-alfa in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor's plasma levels of TNF-alfa were higher. The post-operative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-alfa plasma levels in donors are associated with a higher incidence of PGD.

 Fuente: Transplant International, 2024, 37, 12512

 Editorial: Blackwell Publishing Ltd

 Año de publicación: 2024

 Nº de páginas: 10

 Tipo de publicación: Artículo de Revista

 DOI: 10.3389/ti.2024.12512

 ISSN: 0934-0874,1432-2277

 Url de la publicación: https://doi.org/10.3389/ti.2024.12512

Autoría

SANDIUMENGE, ALBERTO

BELLO, IRENE

COLL-TORRES, ELISABETH

GÓMEZ-BREY, AROA

FRANCO-JARAVA, CLARA

PÉREZ-REDONDO, MARINA

MOSTEIRO, FERNANDO

LAURA SANCHEZ MORENO

CROWLEY, SILVANA

FIEIRA, EVA

SUBERVIOLA, BORJA

MAZO, CRISTOPHER ALAN

AGUSTÍ, ALVAR

PONT, TERESA