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Low-level expression of p-s6 is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

Abstract: Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. The incidence of metastasis for cSCC is estimated to be around 1.2-5%. Ribosomal protein S6 (p-S6) and the p21 protein (p21) are two proteins that play central roles in other cancers. These proteins may be equally important in cSCC, and together, these could constitute a good candidate for metastasis risk assessment of these patients. We investigate the relationship of p-S6 and p21 expression with the impact on the prognosis of head and neck cSCC (cSCCHN). p-S6 and p21 expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 116 patients with cSCCHN and associations sought with clinical characteristics. Kaplan?Meier estimators and Cox proportional hazard regression models were also used. The expression of p-S6 was significantly inversely associated with tumor thickness, tumor size, desmoplastic growth, pathological stage, perineural invasion and tumor buds. p21 expression was significantly inversely correlated with >6 mm tumor thickness, desmoplastic growth, and perineural invasion. p-S6-negative expression significantly predicted an increased risk of nodal metastasis (HR = 2.63, 95% CI 1.51?4.54; p < 0.001). p21 expression was not found to be a significant risk factor for nodal metastasis. These findings demonstrate that p-S6-negative expression is an independent predictor of nodal metastasis. The immunohistochemical expression of p-S6 might aid in better risk stratification and management of patients with cSCCHN

 Fuente: International Journal of Molecular Sciences, 2024, 25(8), 4304

 Editorial: MDPI

 Año de publicación: 2024

 Nº de páginas: 13

 Tipo de publicación: Artículo de Revista

 DOI: 10.3390/ijms25084304

 ISSN: 1661-6596,1422-0067

 Url de la publicación: https://doi.org/10.3390/ijms25084304

Autoría

GÓMEZ DE CASTRO, CELIA

SANTOS JUANES, RAQUEL

NUÑEZ GÓMEZ, BORJA

FERNÁNDEZ VEGA, IVÁN

VIVANCO, BLANCA

FERNÁNDEZ VELASCO, ADELA

REYES GARCÍA, SEBASTIÁN

CARRERO MARTÍN, JIMENA

GARCÍA PEDRERO, JUANA M.

RODRIGO, J.P.

SANTOS JUANES, JORGE

GALACHE, CRISTINA