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Aspirin but not statins is inversely related to gastric cancer with a duration-risk effect: results from the Stomach Cancer Pooling Project Consortium

Abstract: Background: Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC. Methods: A pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted. Two-stage modeling analyses were used to estimate the association between aspirin and statin use and GC after adjusting for potential confounders. Results: The pooled odds ratio (OR) of GC for aspirin users versus nonusers was 0.72 (95% confidence interval [CI], 0.54?0.95). The protective effect of aspirin appeared stronger in individuals without a GC family history (OR, 0.60; 95% CI, 0.37?0.95), albeit with borderline heterogeneity between those with and without a family history (p = .064). The OR of GC decreased with increasing duration of aspirin use, with an OR of 0.41 (95% CI, 0.18?0.95) for durations of ?15 years. An inverse, nonsignificant association with the risk of GC was observed for the use of statins alone (OR, 0.79; 95% CI, 0.52?1.18). Conclusions: These findings suggest that aspirin use, particularly long-term use, is associated with a reduced risk of GC, whereas a similar association was not observed with statins, possibly because of the low frequency of use.

 Autoría: Pastorino R., Pires Marafon D., Sassano M., Hoxhaj I., Pelucchi C., Liao L.M., Rabkin C.S., Sinha R., Lunet N., Morais S., Zaridze D., Maximovich D., Aragonés N., Castaño-Vinyals G., Gómez-Acebo I., López-Carrillo L., López-Cervantes M., Bonzi R., Turati F., Boffetta P., Camargo M.C., Curado M.P., Vioque J., Zhang Z.F., Negri E., La Vecchia C., Boccia S.,

 Fuente: Cancer, 2024, 1-11

 Editorial: Wiley

 Año de publicación: 2024

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.1002/cncr.35510

 ISSN: 0008-543X,1097-0142

 Url de la publicación: https://doi.org/10.1002/cncr.35510

Autoría

PASTORINO, ROBERTA

PIRES MARAFON, DENISE

SASSANO, MICHELE

HOXHAJ, ILDA

PELUCCHI, CLAUDIO

LIAO, LINDA M.

RABKIN, CHARLES S.

SINHA, RASHMI

LUNET, NUNO

MORAIS, SAMANTHA

ZARIDZE, DAVID

MAXIMOVICH, DMITRY

ARAGONÉS, NURIA

CASTAÑO-VINYALS, GEMMA

LÓPEZ-CARRILLO, LIZBETH

LÓPEZ-CERVANTES, MALAQUÍAS

BONZI, ROSSELLA

TURATI, FEDERICA

BOFFETTA, PAOLO